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VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis

  • 编号:
    1A0BC1EF7749BFCB8EB9D0AA3C0A98A7
  • 作者:
    Zhang, Fan(zhangfan)#[1] Tang, Zhongshu[1] Hou, Xu[1] Lennartsson, Johan[2] Li, Yang[1] Koch, Alexander W.[3] Scotney, Pierre[4] Lee, Chunsik[1] Arjunan, Pachiappan[1] Dong, Lijin[1] Kumar, Anil[1] Rissanen, Tuomas T.[5] Wang, Bin[6] Nagai, Nobuo[7] Fons, Pierre[8] Fariss, Robert[1] Zhang, Yongqing[9] Wawrousek, Eric[1] Tansey, Ginger[1] Raber, James[1] Fong, GuoHua[10] Ding, Hao[11] Greenberg, David A.[12] Becker, Kevin G.[9] Herbert, JeanMarc[8] Nash, Andrew[4] YlaHerttuala, Seppo[5] Cao, Yihai[13] Watts, Ryan J.[3] Li, Xuri(lixuri)*[1]
  • 语种:
    英文
  • 期刊:
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA ISSN:0027-8424 2009 年 106 卷 15 期 (6152 - 6157) ; APR 14
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  • 摘要:

    VEGF-B, a homolog of VEGF discovered a long time ago, has not been considered an important target in antiangiogenic therapy. Instead, it has received little attention from the field. In this study, using different animal models and multiple types of vascular cells, we revealed that although VEGF-B is dispensable for blood vessel growth, it is critical for their survival. Importantly, the survival effect of VEGF-B is not only on vascular endothelial cells, but also on pericytes, smooth muscle cells, and vascular stem/progenitor cells. In vivo, VEGF-B targeting inhibited both choroidal and retinal neovascularization. Mechanistically, we found that the vascular survival effect of VEGF-B is achieved by regulating the expression of many vascular prosurvival genes via both NP-1 and VEGFR-1. Our work thus indicates that the function of VEGF-B in the vascular system is to act as a "survival,'' rather than an "angiogenic'' factor and that VEGF-B inhibition may offer new therapeutic opportunities to treat neovascular diseases.

  • 推荐引用方式
    GB/T 7714:
    Zhang Fan,Tang Zhongshu,Hou Xu, et al. VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis [J].PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2009,106(15):6152-6157.
  • APA:
    Zhang Fan,Tang Zhongshu,Hou Xu,Lennartsson Johan,&Li Xuri.(2009).VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis .PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,106(15):6152-6157.
  • MLA:
    Zhang Fan, et al. "VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis" .PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106,15(2009):6152-6157.
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