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Dopaminergic neurons project to the nucleus accumbens regulates anxiety-like behaviors through dopamine D-1 signaling

  • 编号:
    5400F4D6B5055189BB0ED660BCCEF3A3
  • 作者:
    Xie, Yingliang(xieyingliang)#[1] Wang, Peizhen[2] Cui, Xiaoyan[3] Liu, Lei[3] Wang, Pengcheng[1] Jing, Shimei[1] Liu, Qi[1] Wang, Yuting[1] Wang, Shiqiang(wangshiqiang)*[1]
  • 语种:
    英文
  • 期刊:
    BEHAVIOURAL BRAIN RESEARCH ISSN:0166-4328 2022 年 416 卷 ; JAN 7
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  • 关键词:
  • 摘要:

    Dopamine (DA) transmission is important in the regulation of mood and anxiety behaviors. However, how specific dopaminergic signaling pathways respond to anxiogenic stimuli as well as regulate behaviors remains unknown. To understand how DA regulates the animal behaviors under anxiety we performed retrograde labeling and c-Fos staining of midbrain DA neurons. Our c-Fos labeling results showed that DA neurons projected to nucleus accumbens (NAc) are activated in animals treated with the elevated plus-maze (EPM). Real-time measurement of DA release using fast scanning cyclic voltammetry (FSCV) in NAc of freely behaving mice showed that increased DA release and more DA transients in the close arms than the open arms in the EPM. Meanwhile, we also observed a reduction of DA level from the close arms to the open arms. Local infusion of DA D-1 receptor antagonist, SCH23390 in the core of NAc, leads to an anxiolytic-like effect in the open-field and EPM. These anxiolytic effects were not observed in animals received D-2 receptor antagonist sulpiride infusion in the core of NAc. Taken together, our results reveal a novel function of the mesolimbic DA pathway through the D-1 receptor in the regulation of anxiety-like behaviors.

  • 推荐引用方式
    GB/T 7714:
    Xie Yingliang,Wang Peizhen,Cui Xiaoyan, et al. Dopaminergic neurons project to the nucleus accumbens regulates anxiety-like behaviors through dopamine D-1 signaling [J].BEHAVIOURAL BRAIN RESEARCH,2022,416.
  • APA:
    Xie Yingliang,Wang Peizhen,Cui Xiaoyan,Liu Lei,&Wang Shiqiang.(2022).Dopaminergic neurons project to the nucleus accumbens regulates anxiety-like behaviors through dopamine D-1 signaling .BEHAVIOURAL BRAIN RESEARCH,416.
  • MLA:
    Xie Yingliang, et al. "Dopaminergic neurons project to the nucleus accumbens regulates anxiety-like behaviors through dopamine D-1 signaling" .BEHAVIOURAL BRAIN RESEARCH 416(2022).
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