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Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome

  • 编号:
    CE0FDB6A31E2C849E35159DF526EE37D
  • 作者:
    Shi, Yongyong(shiyongyong)#[1,2,3,4] Zhao, Han(zhaohan)#[5,6,7] Shi, Yuhua(shiyuhua)#[5,6,7] Cao, Yunxia(caoyunxia)#[8] Yang, Dongzi(yangdongzi)#[9] Li, Zhiqiang(lizhiqiang)#[1,2,3] Zhang, Bo[10] Liang, Xiaoyan[11] Li, Tao Chen, Jianhua[1,12] Shen, Jiawei[1] Zhao, Junzhao[13] You, Li[5,6,7] Gao, Xuan[5,6,7] Zhu, Dongyi[14] Zhao, Xiaoming[15] Yan, Ying[16] Qin, Yingying[5,6,7] Li, Wenjin[1] Yan, Junhao[5,6,7] Wang, Qingzhong[1] Zhao, Junli[17] Geng, Ling[5,6,7] Ma, Jinlong[5,6,7] Zhao, Yueran[5,6,7] He, Guang[1] Zhang, Aiping[1] Zou, Shuhua[18] Yang, Aijun[19] Liu, Jiayin[20] Li, Weidong[1] Li, Baojie[1] Wan, Chunling[1] Qin, Ying[21] Shi, Juanzi[22] Yang, Jing[23] Jiang, Hong[24] Xu, Jine[25] Qi, Xiujuan[25] Sun, Yun[15] Zhang, Yajie[26] Hao, Cuifang[27] Ju, Xiuqing[28] Zhao, Dongni[29] Ren, ChunE(任春娥)[30] Li, Xiuqing[31] Zhang, Wei[32] Zhang, Yiwen[33] Zhang, Jiangtao[5] Wu, Di[5] Zhang, Changming[5] He, Lin(helin)*[1,2,34,35] Chen, ZiJiang(chenzijiang)*[5,6,7,15]
  • 语种:
    英文
  • 期刊:
    NATURE GENETICS ISSN:1061-4036 2012 年 44 卷 9 期 (1020 - +) ; SEP
  • 收录:
  • 摘要:

    Following a previous genome-wide association study (GWAS 1) including 744 cases and 895 controls, we analyzed genome-wide association data from a new cohort of Han Chinese (GWAS 2) with 1,510 polycystic ovary syndrome (PCOS) cases and 2,016 controls. We followed up significantly associated signals identified in the combined results of GWAS 1 and 2 in a total of 8,226 cases and 7,578 controls. In addition to confirming the three loci we previously reported, we identify eight new PCOS association signals at P < 5 x 10(-8): 9q22.32, 11q22.1, 12q13.2, 12q14.3, 16q12.1, 19p13.3, 20q13.2 and a second independent signal at 2p16.3 (the FSHR gene). These PCOS association signals show evidence of enrichment for candidate genes related to insulin signaling, sexual hormone function and type 2 diabetes (T2D). Other candidate genes were related to calcium signaling and endocytosis. Our findings provide new insight and direction for discovering the biological mechanisms of PCOS.

  • 推荐引用方式
    GB/T 7714:
    Shi Yongyong,Zhao Han,Shi Yuhua, et al. Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome [J].NATURE GENETICS,2012,44(9):1020-+.
  • APA:
    Shi Yongyong,Zhao Han,Shi Yuhua,Cao Yunxia,&Chen Zi-Jiang.(2012).Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome .NATURE GENETICS,44(9):1020-+.
  • MLA:
    Shi Yongyong, et al. "Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome" .NATURE GENETICS 44,9(2012):1020-+.
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