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Advances in the application of Let-7 microRNAs in the diagnosis, treatment and prognosis of leukemia

  • 编号:
    E8170D53362CB6C2915EF97A859F573A
  • 作者:
  • 语种:
    英文
  • 期刊:
    ONCOLOGY LETTERS ISSN:1792-1074 2022 年 23 卷 1 期 ; JAN
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  • 摘要:

    The lethal-7 (Let-7) family of microRNAs (miRNAs) controls the process of development and differentiation, but is also related to the occurrence of tumors and a poor prognosis of patients with tumors. Thus, a more comprehensive exploration of its functions will provide further insights into these processes, and may promote the diagnosis and treatment of tumors. Leukemia is a type of progressive malignant disease, and its pathogenesis involves a variety of epigenetic factors. Amongst the several related epigenetic factors, the Let-7 miRNAs are an important family of molecules that play a crucial role in maintaining a variety of critical biological processes, including development, differentiation and proliferation. In the present study, the role of Let-7 as a tumor suppressor gene and oncogene is reviewed, and the complex regulatory functions of several Let-7 family members in different subtypes of leukemia are described. The current body of knowledge thus far indicates that Let-7 is not only a potential diagnostic and prognostic marker of leukemia, but also a potential therapeutic target for the treatment of affected patients, with particular potential when targeted by adjuvant treatments alongside traditional treatment to improve their survival rate.

  • 推荐引用方式
    GB/T 7714:
    Chen Hao,Wang Jiewei,Wang Huan, et al. Advances in the application of Let-7 microRNAs in the diagnosis, treatment and prognosis of leukemia [J].ONCOLOGY LETTERS,2022,23(1).
  • APA:
    Chen Hao,Wang Jiewei,Wang Huan,Liang Jingru,&Jiang Guosheng.(2022).Advances in the application of Let-7 microRNAs in the diagnosis, treatment and prognosis of leukemia .ONCOLOGY LETTERS,23(1).
  • MLA:
    Chen Hao, et al. "Advances in the application of Let-7 microRNAs in the diagnosis, treatment and prognosis of leukemia" .ONCOLOGY LETTERS 23,1(2022).
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